Lymphatic network drainage resolves cerebral edema and facilitates recovery from experimental cerebral malaria.

Haley, Michael J, Barroso, Ruben, Jasim, Dhifaf A, Haigh, Megan, Green, Jack, Dickie, Ben, Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164, Brough, David and Couper, Kevin N (2024) 'Lymphatic network drainage resolves cerebral edema and facilitates recovery from experimental cerebral malaria.'. Cell Reports, Vol 43, Issue 5, p. 114217.

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Abstract

While brain swelling, associated with fluid accumulation, is a known feature of pediatric cerebral malaria (CM), how fluid and macromolecules are drained from the brain during recovery from CM is unknown. Using the experimental CM (ECM) model, we show that fluid accumulation in the brain during CM is driven by vasogenic edema and not by perivascular cerebrospinal fluid (CSF) influx. We identify that fluid and molecules are removed from the brain extremely quickly in mice with ECM to the deep cervical lymph nodes (dcLNs), predominantly through basal routes and across the cribriform plate and the nasal lymphatics. In agreement, we demonstrate that ligation of the afferent lymphatic vessels draining to the dcLNs significantly impairs fluid drainage from the brain and lowers anti-malarial drug recovery from the ECM syndrome. Collectively, our results provide insight into the pathways that coordinate recovery from CM.

Item Type:	Article
Subjects:	WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WH Hemic and Lymphatic Systems > WH 20 Research (General) WH Hemic and Lymphatic Systems > Lymphatic System > WH 700 Lymphatic system. Lymphatic diseases (General)
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.celrep.2024.114217
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	29 May 2024 12:02
Last Modified:	29 May 2024 12:02
URI:	https://archive.lstmed.ac.uk/id/eprint/24612

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