Poor Diagnostic Accuracy of Commercial Antibody-Based Assays for the Diagnosis of Acute Chikungunya Infection

Blacksell, Stuart D., Tanganuchitcharnchai, Ampai, Jarman, Richard G., Gibbons, Robert V., Paris, Daniel H, Bailey, Mark S., Day, Nicholas P. J., Premaratna, Ranjan, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200 and Janaka de Silva, H. (2011) 'Poor Diagnostic Accuracy of Commercial Antibody-Based Assays for the Diagnosis of Acute Chikungunya Infection'. Clinical and Vaccine Immunology, Vol 18, Issue 10, pp. 1773-1775.

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Abstract

A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.

Item Type:	Article
Uncontrolled Keywords:	Sri Lanka; Chikungunya virus infection
Subjects:	QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology QY Clinical Pathology > QY 4 General works
Faculty: Department:	Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI):	https://doi.org/10.1128/CVI.05288-11
Depositing User:	Users 379 not found.
Date Deposited:	22 Feb 2012 09:46
Last Modified:	06 Feb 2018 13:04
URI:	https://archive.lstmed.ac.uk/id/eprint/2480

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