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Risk factors for mortality in culture-negative neonatal sepsis in Malawi: a propensity score-matched analysis

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Ghambi, Lughano, Chirombo, James, de Baat, Tessa, Kawaza, Kondwani and Iroh Tam, Pui-Ying ORCID: https://orcid.org/0000-0002-3682-8892 (2024) 'Risk factors for mortality in culture-negative neonatal sepsis in Malawi: a propensity score-matched analysis'. BMJ Paediatrics Open, Vol 8, Issue 1, e002664.

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Official URL: https://doi.org/10.1136/bmjpo-2024-002664

Abstract

We conducted a propensity score-matched multivariable regression analysis of 1050 culture-negative neonatal sepsis cases in Malawi, where 160 (15.2%) died. Mortality among neonates with culture-negative sepsis was associated with very low birth weight (adjusted OR (AOR) 12.82, 95% CI 1.23 to 137.49), respiratory distress syndrome (AOR 13.20, 95% CI 2.58 to 83.66), a low Apgar score at 1 min (AOR 3.50, 95% CI 1.21 to 10.72) and at 5 min (AOR 4.77, 95% CI 1.94 to 12.50). Addressing maternal and perinatal factors around health and delivery of care is key to improving outcomes in the context of culture-negative sepsis in neonates from low-income country settings like Malawi.

Item Type:	Article
Subjects:	WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 240 Bacteremia. Sepsis. Toxemias WS Pediatrics > By Age Groups > WS 420 Newborn infants. Neonatology
Faculty: Department:	Education
Digital Object Identifer (DOI):	https://doi.org/10.1136/bmjpo-2024-002664
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	04 Jul 2024 13:58
Last Modified:	04 Jul 2024 13:58
URI:	https://archive.lstmed.ac.uk/id/eprint/24843

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