Inflammation of the Nasal Mucosa is Associated with Susceptibility to Experimental Pneumococcal Challenge in Older Adults.

Urban, Britta ORCID: https://orcid.org/0000-0002-4197-8393, Gonçalves, Andre, Loukov, Dessi, Passos, Fernando, Reiné, Jesús, Gonzalez-Dias, Patricia, Solorzano, Carla, Mitsi, Elena, Nikolaou, Elissavet, O'Connor, Daniel, Collins, Andrea ORCID: https://orcid.org/0000-0002-4094-1572, Adler, Hugh ORCID: https://orcid.org/0000-0003-4437-2298, Pollard, Andrew, Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116, Jochems, Simon P, Nakaya, Helder I and Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 (2024) 'Inflammation of the Nasal Mucosa is Associated with Susceptibility to Experimental Pneumococcal Challenge in Older Adults.'. Mucosal Immunology, Vol 17, Issue 5, pp. 973-989.

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Abstract

Streptococcus pneumoniae colonization in the upper respiratory tract is linked to pneumococcal disease development, predominantly affecting young children and older adults. As the global population ages and comorbidities increase, there is a heightened concern about this infection. We investigated the immunological responses of older adults to pneumococcal controlled human infection by analysing the cellular composition and gene expression in the nasal mucosa. Our comparative analysis with data from a concurrent study in younger adults revealed distinct gene expression patterns in older individuals susceptible to colonization, highlighted by neutrophil activation and elevated levels of CXCL9 and CXCL10. Unlike younger adults challenged with pneumococcus, older adults did not show recruitment of monocytes into the nasal mucosa following nasal colonization. However, older adults who were protected from colonization showed increased degranulation of CD8+ T cells, both before and after pneumococcal challenge. These findings suggest age-associated cellular changes, in particular enhanced mucosal inflammation, that may predispose older adults to pneumococcal colonization.

Item Type:	Article
Subjects:	WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections WT Geriatrics. Chronic Disease > WT 20 Research (General)
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.mucimm.2024.06.010
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	24 Jul 2024 10:53
Last Modified:	10 Oct 2024 13:06
URI:	https://archive.lstmed.ac.uk/id/eprint/24929

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