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Khaki, Jessie J., Meiring, James E., Thindwa, Deus, Henrion, Marc, Jere, Tikhala M., Msuku, Harrison, Heyderman, Robert S., Gordon, Melita A. and Giorgi, Emanuele (2024) 'Modelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods'. Scientific Reports, Vol 14, Issue 1, e17164.
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41598_2024_Article_66436.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Salmonella Typhi is a human-restricted pathogen that is transmitted by the faecal–oral route and causative organism of typhoid fever. Using health facility data from 2016 to 2020, this study focuses on modelling the spatial variation in typhoid risk in Ndirande township in Blantyre. To pursue this objective, we developed a marked inhomogeneous Poisson process model that allows us to incorporate both individual-level and environmental risk factors. The results from our analysis indicate that typhoid cases are spatially clustered, with the incidence decreasing by 54% for a unit increase in the water, sanitation, and hygiene (WASH) score. Typhoid intensity was also higher in children aged below 18 years than in adults. However, our results did not show evidence of a strong temporal variation in typhoid incidence. We also discuss the inferential benefits of using point pattern models to characterise the spatial variation in typhoid risk and outline possible extensions of the proposed modelling framework.
| Item Type: | Article |
|---|---|
| Subjects: | QW Microbiology and Immunology > Bacteria > QW 138 Enterobacteriaceae WC Communicable Diseases > WC 20 Research (General) WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 269 Salmonella infections |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/s41598-024-66436-9 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 07 Aug 2024 15:03 |
| Last Modified: | 07 Aug 2024 15:03 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/25013 |
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