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Vajda, Élodie A., Ross, Amanda, Doum, Dyna, Fairbanks, Emma L., Chitnis, Nakul, Hii, Jeffrey, Moore, Sarah J., Richardson, Jason, Macdonald, Michael, Sovannaroth, Siv, Kimheng, Pen, McIver, David J., Tatarsky, Allison and Lobo, Neil F. (2024) 'Field evaluation of a volatile pyrethroid spatial repellent and etofenprox treated clothing for outdoor protection against forest malaria vectors in Cambodia'. Scientific Reports, Vol 14, Issue 1, e17348.
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41598_2024_Article_67470.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Cambodia’s goal to eliminate malaria by 2025 is challenged by persistent transmission in forest and forest fringe areas, where people are exposed to Anopheles mosquito bites during the day and night. Volatile pyrethroid spatial repellents (VPSRs) and insecticide-treated clothing (ITC) could address these gaps. This study evaluated the outdoor application of one passive transfluthrin-based VPSR, four etofenprox-ITCs paired with a picaridin topical repellent, and a combination of VPSR and ITC against wild Anopheles landing in Cambodia. A 7 × 7 Latin-square study was conducted over 49 collection nights in temporary open structures in Mondulkiri Province. All interventions substantially reduced Anopheles landing, with protective efficacy ranging from 61 to 95%. Mathematical modeling showed significant reductions in vectoral capacity, especially with the combined ITC and VPSR and VPSR alone, albeit with decreased effectiveness over time. These interventions have the potential to reduce outdoor and daytime Anopheles biting, offering valuable contributions to malaria elimination efforts in Cambodia and the Greater Mekong Subregion, contingent upon achieving effective coverage and adherence.
| Item Type: | Article |
|---|---|
| Subjects: | QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control |
| Faculty: Department: | IVCC |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/s41598-024-67470-3 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 08 Aug 2024 10:19 |
| Last Modified: | 08 Aug 2024 10:19 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/25017 |
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