Pathogenesis of Post-Tuberculosis Lung Disease: Defining Knowledge Gaps and Research Priorities at the 2 International Post-Tuberculosis Symposium.

Auld, Sara C, Barczak, Amy K, Bishai, William, Coussens, Anna K, Dewi, Intan M W, Mitini-Nkhoma, Steven C, Muefong, Caleb, Naidoo, Threnesan, Pooran, Anil, Stek, Cari, Steyn, Adrie J C, Tezera, Liku and Walker, Naomi ORCID: https://orcid.org/0000-0002-3345-7694 (2024) 'Pathogenesis of Post-Tuberculosis Lung Disease: Defining Knowledge Gaps and Research Priorities at the 2 International Post-Tuberculosis Symposium.'. American Journal of Respiratory and Critical Care Medicine, Vol 210, Issue 8.

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Abstract

Post-tuberculosis (TB) lung disease (PTLD) is increasingly recognized as a major contributor to the global burden of chronic lung disease, with recent estimates indicating that over half of TB survivors have impaired lung function after successful completion of TB treatment. However, the pathologic mechanisms that contribute to PTLD are not well understood, thus limiting the development of therapeutic interventions to improve long-term outcomes after TB. This report summarizes the work of the "Pathogenesis and Risk Factors Committee" for the Second International Post-Tuberculosis Symposium, which took place in Stellenbosch, South Africa in April 2023. The committee first identified six areas with high translational potential: (1) tissue matrix destruction, including the role of matrix metalloproteinase dysregulation and neutrophil activity, (2) fibroblasts and profibrotic activity, (3) granuloma fate and cell death pathways, (4) mycobacterial factors including pathogen burden, (5) animal models, and (6) the impact of key clinical risk factors including HIV, diabetes, smoking, malnutrition, and alcohol. We share here the key findings from a literature review of those areas, highlighting knowledge gaps and areas where further research is needed.

Item Type:	Article
Subjects:	WA Public Health > Health Administration and Organization > WA 530 International health administration WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Lungs > WF 600 Lungs
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1164/rccm.202402-0374SO
Depositing User:	Rachel Dominguez
Date Deposited:	18 Sep 2024 15:09
Last Modified:	22 Oct 2024 15:43
URI:	https://archive.lstmed.ac.uk/id/eprint/25190

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