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Caputo, Beniamino, De Marco, Carlo M., Pichler, Verena, Bottà, Giordano, Bennett, Kelly L., Amambua-Ngwa, Alfred, Assogba, Sessinou B., Opondo, Kevin O., Clarkson, Chris S., Tennessen, Jacob A., Weetman, David 
ORCID: https://orcid.org/0000-0002-5820-1388, Miles, Alistair and della Torre, Alessandra
(2024)
'Population genomic evidence of a putative ‘far-west’ African cryptic taxon in the Anopheles gambiae complex'. Communications Biology, Vol 7, Issue 1, p. 1115.
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42003_2024_Article_6809.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) | Preview |
Abstract
The two main Afrotropical malaria vectors - Anopheles coluzzii and An. gambiae – are genetically distinct and reproductively isolated across West Africa. However, populations at the western extreme of their range are assigned as “intermediate” between the two species by whole genome sequence (WGS) data, and as hybrid forms by conventional molecular diagnostics. By exploiting WGS data from 1190 specimens collected across west Africa via the Anopheles gambiae 1000 Genomes network, we identified a putative taxon in the far-west (provisionally named Bissau molecular form), which did not arise by admixture but rather may have originated at the same time as the split between An. coluzzii and An. gambiae. Intriguingly, this taxon lacks insecticide resistance mechanisms commonly observed in the two main species. These findings lead to a change of perspective on malaria vector species in the far-west region with potential for epidemiological implications, and a new challenge for genetic-based mosquito control approaches.
| Item Type: | Article |
|---|---|
| Subjects: | QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/s42003-024-06809-y |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 02 Oct 2024 10:54 |
| Last Modified: | 02 Oct 2024 10:54 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/25323 |
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