ICAM-1 can play a major role in mediating P-falciparum adhesion to endothelium under flow

Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164, Gray, Carolyn, McCormick, C. and Turner, G. (2003) 'ICAM-1 can play a major role in mediating P-falciparum adhesion to endothelium under flow'. Molecular and Biochemical Parasitology, Vol 128, Issue 2, pp. 187-193.

Full text not available from this repository.

Abstract

We have investigated the importance of adhesion molecule co-operation in mediating Plasmodium falciparum adhesion to endothelial cells under flow conditions. Using three laboratory parasite lines and a patient isolate which differ in their ICAM-1 and CD36-binding avidity, we found that blockade of ICAM-1 and CD36 separately reduced IRBC adhesion by up to 95 and 50%, respectively. These results confirm previous data showing that ICAM-1 and CD36 synergize to mediate adhesion, but differ in demonstrating that without ICAM-1, binding under flow conditions is severely impaired. Thus, in this system, ICAM-1 is critical for P. falciparum adhesion to activated endothelium and once bound, synergy with CD36 mediates the majority (greater than or equal to98%) of adhesion. (C) 2003 Elsevier Science B.V. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	ICAM-1; CD36; Plasmodium falciparum; Adhesion; HDMEC; HUVEC
Subjects:	QS Anatomy > Histology > QS 532.5.E7 Epithelium QW Microbiology and Immunology > QW 52 Physiology and chemistry of microorganisms. Metabolism. WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/s0166-6851(03)00075-6
Depositing User:	Users 494 not found.
Date Deposited:	25 Feb 2013 12:11
Last Modified:	17 Jul 2019 14:14
URI:	https://archive.lstmed.ac.uk/id/eprint/2557

Statistics

View details

Actions (login required)

Edit Item