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ICAM-1 can play a major role in mediating P-falciparum adhesion to endothelium under flow

Craig, Alister ORCID:, Gray, Carolyn, McCormick, C. and Turner, G. (2003) 'ICAM-1 can play a major role in mediating P-falciparum adhesion to endothelium under flow'. Molecular and Biochemical Parasitology, Vol 128, Issue 2, pp. 187-193.

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We have investigated the importance of adhesion molecule co-operation in mediating Plasmodium falciparum adhesion to endothelial cells under flow conditions. Using three laboratory parasite lines and a patient isolate which differ in their ICAM-1 and CD36-binding avidity, we found that blockade of ICAM-1 and CD36 separately reduced IRBC adhesion by up to 95 and 50%, respectively. These results confirm previous data showing that ICAM-1 and CD36 synergize to mediate adhesion, but differ in demonstrating that without ICAM-1, binding under flow conditions is severely impaired. Thus, in this system, ICAM-1 is critical for P. falciparum adhesion to activated endothelium and once bound, synergy with CD36 mediates the majority (greater than or equal to98%) of adhesion. (C) 2003 Elsevier Science B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: ICAM-1; CD36; Plasmodium falciparum; Adhesion; HDMEC; HUVEC
Subjects: QS Anatomy > Histology > QS 532.5.E7 Epithelium
QW Microbiology and Immunology > QW 52 Physiology and chemistry of microorganisms. Metabolism.
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):
Depositing User: Users 494 not found.
Date Deposited: 25 Feb 2013 12:11
Last Modified: 17 Jul 2019 14:14


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