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PitolGarcia, Ana, Richards, Siobhan, Mirindi, Patrick, Mahamed, Hibak O., Baller, April, Hughes, Grant 
ORCID: https://orcid.org/0000-0002-7567-7185 and Beck, Sara E.
(2024)
'Efficacy of Disinfectants for Monkeypox Virus Inactivation on High Touch Surface Materials in Low-Resource Settings'. Environmental Science & Technology, Vol 58, Issue 45, e19907-20328.
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pitol-et-al-2024-efficacy-of-disinfectants-for-monkeypox-virus-inactivation-on-high-touch-surface-materials-in-low.pdf - Published Version Available under License Creative Commons Attribution. Download (5MB) | Preview |
Abstract
Disinfection efficacy tests were conducted on surface carriers inoculated with the monkeypox virus (MPXV) by applying six disinfectant solutions (and three controls) on six surfaces common in low-resource settings: four nonporous surfaces (stainless steel, glass, plastic, and latex) and two porous surfaces (ceramic and wood). Disinfectants were wiped on carriers in triplicate, with a 1 min contact time: 0.05 and 0.5% sodium hypochlorite, 70% ethanol, two quaternary ammonium compound (QAC)-based disinfectants, and 1.4% hydrogen peroxide. MPXV was then quantified, and log10 removal values were calculated. Sodium hypochlorite (0.05 and 0.5%) and ethanol (70%) removed MPXV to below detection level, ≥ 99.97% reduction for nonporous surfaces, and ≥99.40% for wood, QAC-based disinfectants were efficacious on nonporous surfaces (≥99.97% inactivation) but had diminished efficacy on wood, a porous surface, and 1.4% H2O2 had limited efficacy across all tested surfaces. Results varied by disinfectant type and surface type. Based on our results, we recommend using 0.05% sodium hypochlorite or 70% ethanol with 1 min contact time to inactive MPXV on clean nonporous and porous surfaces. As MPXV is evolving, future research with additional disinfectants, application methods, and environmental conditions and research to understand adsorption, disinfection efficacy, and transmission risk on porous surfaces are needed to develop practical disinfection recommendations.
| Item Type: | Article |
|---|---|
| Subjects: | QV Pharmacology > Local Anti-Infective Agents. Dyes. Tars > QV 220 Local anti-infective agents. Disinfectants WC Communicable Diseases > Virus Diseases > General Virus Diseases > WC 500 Virus diseases (General or not elsewhere classified) |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1021/acs.est.4c09821 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 18 Nov 2024 15:30 |
| Last Modified: | 18 Nov 2024 15:30 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/25581 |
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