Aedes aegypti control in breeding sites through an insecticidal coating with dual effect: Laboratory trials and safety assessment

Cárdenas, Rocio, Cabrera, Olga L., Carrillo, Maria A., Pineda, Alejandra, Ahumada, Martha L., Yañez, Yohana, Ismail, Hanafy ORCID: https://orcid.org/0000-0002-9953-9588, Paine, Mark ORCID: https://orcid.org/0000-0003-2061-7713, Rivera, Tatiana and Kroeger, Axel (2024) 'Aedes aegypti control in breeding sites through an insecticidal coating with dual effect: Laboratory trials and safety assessment'. Medical and Veterinary Entomology. (In Press)

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Abstract

Ground water tanks are known to be preferred Aedes aegypti oviposition places providing opportunities for adult and larvae control. Therefore, a dual‐effect insecticidal coating (IC) (alphacypermethrin/ pyriproxyfen) with a slow‐release mechanism and safe for users could be applied within Aedes spp. breeding sites, representing a promising option. Bioassays were designed to determine the mortality and sterilizing effects on gravid mosquitoes exposed to IC. The effect of inhibition of emergence was evaluated in eggs, larvae and pupae exposed in different containers. For the water safety assessment concentrations of active ingredients were determined by reverse phase high performance liquid chromatography (RP‐HPLC) and the health risk was calculated. The IC applied to the interior walls of water‐holding containers showed efficacy against Ae. aegypti in terms of high gravid‐female mortality (81% at 24 h, p < 0.01), sterilizing effect (inhibition of oviposition by 63%, p < 0.01) and emergence inhibition (100% in eggs, L3 and L4; 97% in pupae). The offspring rate was reduced [only 0.15 (38/250) new adults emerged per exposed gravid females as against 11.90 per unexposed female (2976/250) at baseline]. Emergence inhibition was recorded up to 12 months and adult mortality >80% up to 6 months. The use of water stored in treated containers, either for washing or drinking, is not expected to pose a health risk to users. IC applied to domestic water containers has dual and complementary action that reduces Ae. aegypti densities (immature and adult stages). This represents baseline information for a cluster randomized efficacy trial in Colombia.

Item Type:	Article
Subjects:	QX Parasitology > QX 20 Research (General) QX Parasitology > Insects. Other Parasites > QX 525 Aedes QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1111/mve.12776
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	26 Nov 2024 12:00
Last Modified:	26 Nov 2024 12:00
URI:	https://archive.lstmed.ac.uk/id/eprint/25618

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