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Management and outcome of tuberculosis patients who fail treatment under routine programme conditions in Malawi

Harries, A. D., Nyirenda, T. E., Kemp, J., Squire, Bertie ORCID:, Godfrey-Faussett, P. and Salaniponi, F. M. L. (2003) 'Management and outcome of tuberculosis patients who fail treatment under routine programme conditions in Malawi'. International Journal of Tuberculosis and Lung Disease, Vol 7, Issue 11, pp. 1040-1044.

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SETTING: All 43 non-private hospitals (three central, 22 district and 18 mission) in Malawi that registered and treated TB cases between 1 July 1999 and 30 June 2000. OBJECTIVES: To determine 1) the number of new smear-positive PTB patients who failed treatment, 2) the management of patients who failed, 3) their treatment outcome and 4) culture and drug sensitivity results. DESIGN: Retrospective data collection using TB registers and laboratory culture and drug sensitivity registers. RESULTS: Ninety patients failed treatment, 60 (67%) at 5 months and 3 0 (3 3 %) at the end of treatment. Sixty-four (71%) failure patients were registered and commenced on anti-tuberculosis treatment. Of these, 95% were registered in the same hospital as before, 89% were given a different TB registration number, 67% were correctly registered as 'failures' and 61% were treated within one month of failing the previous regimen. Forty-eight (75%) retreated patients were cured. Only 31 (34%) of the 90 patients had sputum sent for culture and drug sensitivity testing. In 11 patients with cultures of M. tuberculosis, eight were fully sensitive and three had mono-resistance to isoniazid. CONCLUSION: While the outcome of failure patients who start retreatment is good, there are several programmatic deficiencies that need to be corrected.

Item Type: Article
Subjects: WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
WF Respiratory System > Tuberculosis > WF 310 Therapy
WF Respiratory System > Tuberculosis > WF 330 Hospitalization. Climatotherapy. Heliotherapy
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Depositing User: Ms Julia Martin
Date Deposited: 28 Jun 2012 04:41
Last Modified: 13 Nov 2019 11:21


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