Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?

Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Corbel, V., Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388, Wilding, Craig, Williamson, M. S. and Black, W. C. (2009) 'Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?'. Trends in Parasitology, Vol 25, Issue 5, pp. 213-219.

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Abstract

Several groups are developing and applying DNA-based technologies to monitor insecticide-based disease control programmes. However, several recent papers have concluded that the knockdown resistance (kdr) genotype-phenotype correlation that is observed in a wide variety of taxa might not hold in all mosquitoes. In this article, we review the evidence to support this putative breakdown and argue that the conclusion follows from unreliable data or the unparsimonious interpretation of data. We assert that the link between kdr genotype and DDT- and pyrethroid-susceptibility phenotype is clear. However, we emphasize that kdr genotype might explain only a portion of heritable variation in resistance and that diagnostic assays to test the importance of other resistance mechanisms in field populations are required.

Item Type:	Article
Additional Information:	Donnelly, Martin J. Corbel, Vincent Weetman, David Wilding, Craig S. Williamson, Martin S. Black, William C.
Subjects:	QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.pt.2009.02.007
Depositing User:	Users 183 not found.
Date Deposited:	14 Jun 2010 13:51
Last Modified:	16 Sep 2019 09:16
URI:	https://archive.lstmed.ac.uk/id/eprint/257

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