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PitolGarcia, Ana, Richards, Siobhan, Mirindi, Patrick, Mahamed, Hibak O, Baller, April, Hughes, Grant 
ORCID: https://orcid.org/0000-0002-7567-7185 and Beck, Sara E
(2024)
'Efficacy of laundry practices in eliminating monkeypox virus (MPXV) from fabrics'. The Journal of Infectious Diseases.
(In Press)
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jiae606.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (546kB) | Preview |
Abstract
Background
The declaration of mpox as a public health emergency of international concern highlights the need for interventions to interrupt virus transmission, including transmission via fabrics. Current World Health Organization (WHO) guidance on clothes washing is based on a general consensus of virus inactivation; however, there is uncertainty about the efficacy of laundry detergents and disinfectants or the reduction of risk achieved by washing clothes for mpox virus (MPXV) specifically.
Methods
This study investigates the efficacy of manual washing for inactivating MPXV from clothes. Using a simulated washing method, we evaluated the efficacy of commonly used laundry products and high temperature water for inactivating MPXV on fabrics. Cotton and polyester fabrics were inoculated with MPXV for 1 minute, placed in a microcentrifuge tube containing water or water with test product for 20 minutes, with agitation every 5 minutes to simulate manual washing.
Results
Sodium hypochlorite, liquid sanitizer, and 2 powdered laundry detergents dissolved in room temperature water, as well as 70°C water alone, completely inactivated MPXV (>3 log10 reduction or >99.9% inactivation) on both cotton and polyester fabrics.
Conclusions
Given the expected concentrations of MPXV on fabrics, the low transfer rate of viruses from porous surfaces to skin, the effective inactivation of laundry processes, and the expected doses required for infection, we expect the risk of transmission after laundering contaminated fabrics to be low. This study provides evidence to support WHO guidance for MPXV inactivation, reducing the viral load on fabrics to prevent the spread of mpox in both health care and household settings.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WC Communicable Diseases > Virus Diseases > Infectious Viral Skin Diseases > WC 570 Infectious viral skin diseases |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1093/infdis/jiae606 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 13 Jan 2025 14:55 |
| Last Modified: | 13 Jan 2025 14:55 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/25857 |
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