Landscape of guidance documents used at TropNet and GeoSentinel centres for the clinical management of schistosomiasis outside endemic areas: a systematic appraisal

Tamarozzi, Francesca, Mazzi, Cristina, Antinori, Spinello, Arsuaga, Marta, Becker, Sören L., Bocanegra, Cristina, Bottieau, Emmanuel, Buonfrate, Dora, Bustinduy, Amaya L., Camprubí-Ferrer, Daniel, Caumes, Eric, Duvignaud, Alexandre, Grobusch, Martin P., Huits, Ralph, Jaureguiberry, Stephane, Jordan, Sabine, Mueller, Andreas, Ndao, Momar, Neumayr, Andreas, Perez-Molina, Jose A., Pettersen, Frank O., Rothe, Camilla, Salas-Coronas, Joaquin, Salvador, Fernando, Stothard, Russell ORCID: https://orcid.org/0000-0002-9370-3420, Tomasoni, Lina R., van Hellemond, Jaap J., van Lieshout, Lisette, Vaughan, Stephen D., Wammes, Linda J., Yansouni, Cedric P., Zammarchi, Lorenzo and Gobbi, Federico G. (2025) 'Landscape of guidance documents used at TropNet and GeoSentinel centres for the clinical management of schistosomiasis outside endemic areas: a systematic appraisal'. Travel Medicine and Infectious Disease, Vol 64, p. 102822.

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Abstract

Background
The diagnostic and treatment approaches for schistosomiasis in individual patients, outside endemic areas, are not standardised. This study aimed to appraise the reference documents that the experts from the TropNet and GeoSentinel networks use in practice as guidance for the clinical management of their patients with (suspect) schistosomiasis.

Methods
We systematically appraised the following data from the referenced guidance documents: i) document type, ii) case definitions, iii) diagnostic techniques envisaged; iv) treatment recommendations; v) follow-up recommendations; vi) screening recommendations, and vii) symptom-based diagnostic suspicion.

Results
Twenty-two of the 30 responders (73.3%) indicated 19 reference documents, three of which were WHO material not intended for individual clinical management. Only 4/19 (21.1%) documents were national recommendations; no international guideline was indicated. Case definitions were explicitly presented in only one document (1/19; 5.3%). Diagnostic tools were detailed in 11/16 (68.8%) and follow-up guidance in 8/16 (50%) documents. Treatment guidance was provided in 14/16 (87.5%) documents.

Conclusions
Heterogeneity in clinical guidance was evident, although with noticeable overlap at least for chronic schistosomiasis. This confirms the need to formalise case definitions, which should be used to design trials to rigorously assess diagnostic tools and treatment schemes, and eventually come to harmonisation of clinical management guidance.

Item Type:	Article
Subjects:	WA Public Health > WA 30 Socioeconomic factors in public health (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.tmaid.2025.102822
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	19 Mar 2025 15:12
Last Modified:	19 Mar 2025 15:46
URI:	https://archive.lstmed.ac.uk/id/eprint/26225

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