Risk stratification during antenatal care failed to identify most mothers who experienced adverse pregnancy outcomes: A prospective study from Kakamega County, Kenya

Cooper, Jan E., Kruk, Margaret, Kapaon, David, Opondo, Kennedy, Nzinga, Jacinta, Kosgei, Rose J. and Croke, Kevin (2025) 'Risk stratification during antenatal care failed to identify most mothers who experienced adverse pregnancy outcomes: A prospective study from Kakamega County, Kenya'. Tropical Medicine & International Health. (In Press)

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Abstract

Introduction
Risk stratification of pregnancies informs clinical care globally. Yet recent research has cast doubt on the ability of currently used population-level risk measures to accurately predict poor outcomes at the individual level. We examine the assumption that existing forms of risk stratification can successfully identify women likely to develop complications during delivery in a rural setting in Kenya.

Methods
We conducted a prospective observational study of 19,653 pregnant women in Kakamega County in Western Kenya. Women were contacted three times during the perinatal period and surveyed about provider-identified risks and self-assessed concerns about pregnancy complications, delivery process outcomes, and adverse delivery outcomes. Measures of risk were derived from women's self-reporting. We compared delivery process outcomes and adverse delivery outcomes between high- and low-risk pregnancies, and between women with and without expressed concerns about delivery complications. Delivery process outcomes included intrapartum referral, unplanned caesarean section, blood transfusion, hysterectomy, or admission to an intensive care unit. Adverse delivery outcomes included stillbirth, neonatal mortality, and maternal mortality. We reported means and confidence intervals for each category, and tested for differences using bivariate linear regression.

Results
Thirty-eight percent of pregnancies had at least one risk factor consistent with a high risk pregnancy; the remaining 62% were low risk by this criteria. Rates of most adverse process outcomes and delivery outcomes were higher among pregnancies with known risks. However, 64.5% of maternal deaths and 54.8% of all deaths in the sample took place among pregnancies characterised as low risk.

Conclusions
Risk stratification using existing indicators of risk during pregnancy is inadequate to identify women at risk of adverse health outcomes in this setting.

Item Type:	Article
Subjects:	WA Public Health > WA 30 Socioeconomic factors in public health (General) WQ Obstetrics > Pregnancy Complications > WQ 240 Pregnancy complications (General)
Faculty: Department:	Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1111/tmi.14110
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	17 Apr 2025 11:28
Last Modified:	17 Apr 2025 11:28
URI:	https://archive.lstmed.ac.uk/id/eprint/26503

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