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IL-4 dependent resistance to the tapeworm Mesocestoides corti (Cestoda) in mice

Rawat, Jagveer, Dixon, John B., Macintyre, Andrew R., McGarry, Helen F. and Taylor, Mark ORCID: (2003) 'IL-4 dependent resistance to the tapeworm Mesocestoides corti (Cestoda) in mice'. Parasite Immunology, Vol 25, Issue 11-12, pp. 553-557.

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Three-week Mesocestoides corti infections of C57BL/6 mice showed significantly raised parasite counts in animals with a targeted knockout of the IL-4 gene. By contrast, antibody neutralization of IL-5 and inhibition of eosinophilia had no effect on parasite numbers. In SV/129 mice, knockout of the interferon gamma receptor and inducible nitric oxide synthase genes had no significant effect on parasite counts. In IL-4(-/-)mice the dominant IgG1 antibody response was dramatically reduced, with a concomitant increase in IgG2a/b responses and a partial twofold reduction in IgM and IgE responses. We conclude that murine resistance to M. corti is dependent on IL-4, but occurs independently of IL-5 and eosinophils. This provides the first direct evidence for IL-4 mediated immunity of mice to infection with a tissue-dwelling platyhelminth.

Item Type: Article
Uncontrolled Keywords: Mesocestoides corti;IL-4;IL-5;targeted knockout;mouse;eosinophil;T cell
Subjects: QW Microbiology and Immunology > Immunity by Type > QW 541 Natural immunity. Immunogenetics
QX Parasitology > Helminths. Annelida > QX 400 Cestoda
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):
Depositing User: Ms Julia Martin
Date Deposited: 19 Jul 2012 09:23
Last Modified: 16 Sep 2019 09:01


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