Is colloidal oat an effective emollient ingredient for the prevention and treatment of atopic dermatitis in infants?

Fowler, Joseph F., Ma, Lin, Bergman, James, Horowitz, Paul, Lavender, Tina, Eichenfield, Lawrence F., Draelos, Zoe, Danby, Simon G. and Cork, Michael J. (2025) 'Is colloidal oat an effective emollient ingredient for the prevention and treatment of atopic dermatitis in infants?'. Journal of Dermatological Treatment, Vol 36, Issue 1, e2487945.

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Abstract

Background
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by barrier dysfunction and immune dysregulation, often leading to increased allergen penetration, sensitization, and secondary infections. Colloidal oat emollients are widely used in adult AD management, but their role in pediatric AD treatment, prevention, and allergy modulation remains under investigation.

Methods
A comprehensive literature review evaluated clinical and preclinical studies on colloidal oat-containing emollients in pediatric AD treatment and prevention. Studies assessing skin barrier function, immune modulation, AD prevention, food allergy risk, and healthcare utilization were included.

Results
Colloidal oat emollients improved skin hydration, reduced transepidermal water loss (TEWL), and supported barrier repair, leading to fewer AD flares and reduced reliance on steroid treatments. Studies suggest that early, consistent use of advanced emollient formulations may lower AD incidence in high-risk infants and reduce food sensitization rates. Real-world data indicate that patients using colloidal oat emollients have fewer clinic visits and lower overall healthcare costs. Concerns about oat sensitization remain unsubstantiated in most studies.

Conclusion
Colloidal oat emollients are effective, well-tolerated, and cost-efficient for pediatric AD management. Their barrier-restorative and anti-inflammatory properties may reduce AD and allergy risk. Future research should focus on head-to-head emollient comparisons to optimize treatment strategies.

Item Type:	Article
Subjects:	WR Dermatology > WR 20 Research (General) WS Pediatrics > WS 20 Research (General)
Faculty: Department:	Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1080/09546634.2025.2487945
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	07 May 2025 13:34
Last Modified:	07 May 2025 13:34
URI:	https://archive.lstmed.ac.uk/id/eprint/26647

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