Domestic smoke exposure is associated with alveolar macrophage particulate load

Fullerton, Duncan, Jere, K., Jambo, Kondwani ORCID: https://orcid.org/0000-0002-3195-2210, Kulkarni, N. S., Zijlstra, E. E., Grigg, J., French, Neil, Molyneux, Malcolm E and Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 (2009) 'Domestic smoke exposure is associated with alveolar macrophage particulate load'. Tropical Medicine & International Health, Vol 14, Issue 3, pp. 349-354.

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Abstract

Indoor air pollution is associated with impaired respiratory health. The pre-dominant indoor air pollutant to which two billion of the world's population is exposed is biomass fuel smoke. We tested the hypothesis that reported smoke exposure in men and women is associated with increased alveolar macrophage uptake of biomass smoke particulates.
Healthy volunteers attending for research bronchoscopy in Malawi completed a questionnaire assessment of smoke exposure. Particulate matter visible in alveolar macrophages (AM) was quantified using digital image analysis. The geometric mean of the percentage area of the cytoplasm occupied by particulates in 50 cover-slip adherent AM was calculated and termed particulate load.
In 57 subjects (40 men and 17 women) there was a significant difference between the particulate load in groups divided according to pre-dominant lighting form used at home (anovaP = 0.0009) and type of cooking fuel (P = 0.0078).
Particulate load observed in macrophages is associated with the reported type of biomass fuel exposure. Macrophage function in relation to respiratory health should now be investigated in biomass smoke exposed subjects.

Item Type:	Article
Uncontrolled Keywords:	indoor air pollution biomass fuel alveolar macrophages human immunodeficiency virus particulate matter indoor air-pollution obstructive pulmonary-disease biomass smoke lung-function developing-countries health particles children population infections
Subjects:	WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WA Public Health > Sanitation. Environmental Control > General Sanitation and Environmental Control > WA 670 General works WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Disorders and Injuries of Environmental Origin > WD 600 General works WF Respiratory System > WF 20 Research (General)
Faculty: Department:	Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI):	https://doi.org/10.1111/j.1365-3156.2009.02230.x
Depositing User:	Users 43 not found.
Date Deposited:	22 Jun 2010 13:56
Last Modified:	17 Aug 2022 08:55
URI:	https://archive.lstmed.ac.uk/id/eprint/272

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