Trichomonas vaginalis pathobiology new insights from the genome sequence.

Hirt, Robert P, de Miguel, Natalia, Nakjang, Sirintra, Dessi, Daniele, Liu, Yuk-Chien, Diaz, Nicia, Rappelli, Paola, Acosta Serrano, Alvaro ORCID: https://orcid.org/0000-0002-2576-7959, Fiori, Pier-Luigi and Mottram, Jeremy C (2011) 'Trichomonas vaginalis pathobiology new insights from the genome sequence.'. Advances in Parasitology, Vol 77, pp. 87-140.

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Abstract

The draft genome of the common sexually transmitted pathogen Trichomonas vaginalis encodes one of the largest known proteome with 60,000 candidate proteins. This provides parasitologists and molecular cell biologists alike with exciting, yet challenging, opportunities to unravel the molecular features of the parasite's cellular systems and potentially the molecular basis of its pathobiology. Here, recent investigations addressing selected aspects of the parasite's molecular cell biology are discussed, including surface and secreted virulent factors, membrane trafficking, cell signalling, the degradome, and the potential role of RNA interference in the regulation of gene expression.

Item Type:	Article
Subjects:	QX Parasitology > Protozoa > QX 50 Protozoa QX Parasitology > Protozoa > QX 70 Mastigophora. (e.g., Giardia. Trichomonas. Trypanosoma. Leishmania) WC Communicable Diseases > Sexually Transmitted Diseases > WC 140 Sexually transmitted diseases
Digital Object Identifer (DOI):	https://doi.org/10.1016/B978-0-12-391429-3.00006-X
Depositing User:	Mary Creegan
Date Deposited:	13 Mar 2012 17:09
Last Modified:	27 Sep 2019 15:29
URI:	https://archive.lstmed.ac.uk/id/eprint/2813

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