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Cobelens, Frank, van den Hof, Susan, Pai, Madhuker, Squire, Bertie 
ORCID: https://orcid.org/0000-0001-7173-9038, Ramsay, Andrew and Kimberling, Michael E.
(2012)
'Which new diagnostics for tuberculosis, and when?'. Journal of Infectious Disease, Vol 205, Issue Supp 2, S191-S198.
Abstract
Recently, new diagnostic tools for tuberculosis detection and resistance testing have become available. The World Health Organization endorses new tuberculosis diagnostics by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process. This endorsement process takes place when limited evidence beyond test accuracy is available. There is a need to provide guidance to tuberculosis programs about which new diagnostics to scale up and how best to position them in diagnostic algorithms. To speed adoption of new diagnostics for tuberculosis, the policy recommendation process should be revised to consist of 2 steps: technical recommendation and programmatic recommendation. Technical recommendation would follow the GRADE process and be based on accuracy with limited cost and feasibility data, while programmatic recommendation would include patient-important outcomes, cost-effectiveness when implemented under routine conditions, and factors critical to successful scale-up. The evidence for both steps should be systematically collected, but each requires different study designs.
PMID: 22476716 [PubMed - indexed for MEDLINE]
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis |
| Digital Object Identifer (DOI): | https://doi.org/10.1093/infdis/jis188 |
| Related URLs: | |
| Depositing User: | Helen Rigby |
| Date Deposited: | 23 Jul 2012 15:07 |
| Last Modified: | 03 Dec 2024 12:40 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/2866 |
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