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Fibrinogen binding to intercellular adhesion molecule 1: Implications for Plasmodium falciparum adhesion

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Gray, Carolyn and Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 (2002) 'Fibrinogen binding to intercellular adhesion molecule 1: Implications for Plasmodium falciparum adhesion'. Infection and Immunity, Vol 70, Issue 7, pp. 3962-3964.

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Official URL: http://iai.asm.org/content/70/7/3962

Abstract

Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.

Item Type:	Article
Subjects:	QU Biochemistry > Cells and Genetics > QU 375 Cell physiology QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 695 Parasitic diseases (General) WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 310 Mechanism of blood coagulation. Hemostatis
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1128/IAI.70.7.3962-3964.2002
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	21 Aug 2013 11:01
Last Modified:	17 Jul 2019 14:14
URI:	https://archive.lstmed.ac.uk/id/eprint/2928

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