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Pisell, T. L., Hoffmann, I. F., Jere, C. S., Ballard, S. B., Molyneux, Malcolm E, Butera, S. T. and Lawn, S. D. (2002) 'Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfection'. AIDS, Vol 16, Issue 11, pp. 1503-1509.
Full text not available from this repository.Abstract
Objectives: To determine the impact of Plasmodium falciparum malaria coinfection and its treatment on cellular reservoirs of viral replication in HIV-1-infected persons and to relate this to changes in systemic immune activation. Methods: Plasma samples were obtained from HIV-1-infected individuals (n = 10) at diagnosis of acute malaria, 4 weeks after parasite clearance and from HIV-infected aparasitemic controls (n = 10). Immunomagnetic HIV-1 capture analysis was used to determine the cellular origin of cell-free virus particles present in all 30 plasma samples and indices of immune activation were measured using enzyme-linked immunosorbent assays. Results: Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. Parasite clearance following treatment with antimalarial drugs resulted in decreased detection of HIV-1 particles derived from the CD14 macrophage cell subset and correlated with a marked diminution in systemic immune activation. Conclusions: Acute P. falciparum malaria coinfection impacts virus-host dynamics in HIV-1-infected persons at the cellular level, notably showing a reversible induction of HIV-1 replication in CD14 macrophages that is associated with changes in immune activation.
| Item Type: | Article |
|---|---|
| Subjects: | QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General) QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WH Hemic and Lymphatic Systems > Lymphatic System > WH 650 Reticuloendothelial system |
| Faculty: Department: | Groups (2002 - 2012) > Clinical Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1097/00002030-200207260-00007 |
| Depositing User: | Lynn Roberts-Maloney |
| Date Deposited: | 17 Jul 2013 10:21 |
| Last Modified: | 17 Aug 2022 08:56 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/2974 |
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