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Ramaley, Patricia A., French, Neil, Kaleebu, Pontiano, Gilks, C.F., Whitworth, James and Hill, Adrian V. S. (2002) 'HIV in Africa - Chemokine-receptor genes and AIDS risk'. Nature, Vol 417, Issue 6885, p. 140.
Full text not available from this repository.Abstract
Schliekelman et al.1 have provided a model to quantify the speed at which HIV-resistance haplotypes can become enriched in a susceptible population through a delay in the onset of AIDS, permitting greater lifetime reproduction and the selection of AIDS-delaying haplotypes. But we question their conclusion1 that there could be a rapid evolution of resistance to AIDS onset in some African populations if the current HIV epidemic persists, as this depends on an untested assumption: that variant forms of the chemokine-receptor-5 (CCR5) gene impart selective advantages or disadvantages in Africa that are comparable to those reported for African Americans2, 3, 4, 5, 6. Here we test this premise in a large Ugandan population, and find that CCR5 variants are not associated with HIV/AIDS disease risk in Africa — the origin and centre of the current AIDS pandemic. This gene may therefore not be subject to rapid evolutionary change as a result of the HIV epidemic in Africa.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Genetics > QU 475 Genetic processes WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/417140a |
| Depositing User: | Lynn Roberts-Maloney |
| Date Deposited: | 27 Jun 2013 09:20 |
| Last Modified: | 21 Nov 2019 14:17 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/2976 |
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