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HIV in Africa - Chemokine-receptor genes and AIDS risk

Ramaley, Patricia A., French, Neil, Kaleebu, Pontiano, Gilks, C.F., Whitworth, James and Hill, Adrian V. S. (2002) 'HIV in Africa - Chemokine-receptor genes and AIDS risk'. Nature, Vol 417, Issue 6885, p. 140.

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Schliekelman et al.1 have provided a model to quantify the speed at which HIV-resistance haplotypes can become enriched in a susceptible population through a delay in the onset of AIDS, permitting greater lifetime reproduction and the selection of AIDS-delaying haplotypes. But we question their conclusion1 that there could be a rapid evolution of resistance to AIDS onset in some African populations if the current HIV epidemic persists, as this depends on an untested assumption: that variant forms of the chemokine-receptor-5 (CCR5) gene impart selective advantages or disadvantages in Africa that are comparable to those reported for African Americans2, 3, 4, 5, 6. Here we test this premise in a large Ugandan population, and find that CCR5 variants are not associated with HIV/AIDS disease risk in Africa — the origin and centre of the current AIDS pandemic. This gene may therefore not be subject to rapid evolutionary change as a result of the HIV epidemic in Africa.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 475 Genetic processes
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
Digital Object Identifer (DOI):
Depositing User: Lynn Roberts-Maloney
Date Deposited: 27 Jun 2013 09:20
Last Modified: 21 Nov 2019 14:17


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