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Jambo, Kondwani C., Sepako, Enoch, Heyderman, Robert S. and Gordon, Stephen 
ORCID: https://orcid.org/0000-0001-6576-1116
(2010)
'Potential role for mucosally active vaccines against pneumococcal pneumonia'. Trends in Microbiology, Vol 18, Issue 2, pp. 81-89.
Abstract
Pneumococcal pneumonia is a life-threatening disease with high mortality and morbidity among children under 5 years of age, the elderly and immunocompromised individuals worldwide. Protection against pneumococcal pneumonia relies on successful regulation of colonisation in the nasopharynx and a brisk alveolar macrophage-mediated immune response in the lung. Therefore, enhancing pulmonary mucosal immunity (which includes a combination of innate, humoral and cell-mediated immunity) through mucosal vaccination might be the key to prevention of pneumococcal infection. Current challenges include a lack of information in humans on mucosal immunity against pneumococci and a lack of suitable adjuvants for new vaccines. Data from mouse models, however, suggest that mucosally active vaccines will enhance mucosal and systemic immunity for protection against pneumococcal infection.
| Item Type: | Article |
|---|---|
| Additional Information: | This article is an Elsevier "Open Access" article and is available at: http://www.sciencedirect.com/science/article/pii/S0966842X09002571 |
| Subjects: | QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 204 Pneumococcal pneumonia. Staphylococcal pneumonia |
| Faculty: Department: | Groups (2002 - 2012) > Clinical Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.tim.2009.12.001 |
| Depositing User: | Users 379 not found. |
| Date Deposited: | 07 Nov 2012 09:49 |
| Last Modified: | 07 Oct 2019 08:23 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/3042 |
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