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Arana, B. A., Mendoza, C. E., Rizzo, N. R. and Kroeger, Axel (2001) 'Randomized, controlled, double-blind trial of topical treatment of cutaneous leishmaniasis with paromomycin plus methylbenzethonium chloride ointment in Guatemala'. American Journal of Tropical Medicine and Hygiene, Vol 65, Issue 5, pp. 466-470.
Full text not available from this repository.Abstract
A double-blind, randomized trial was undertaken in Guatemala to determine the therapeutic efficacy of an ointment for the treatment of cutaneous leishmaniasis that contained 15% paromomycin and 12% methylbenzethonium chloride and that was applied twice a day for 20 days. The treatment group included 35 patients, and the placebo group included 33 patients. The initial clinical response rate (13 weeks after completing the treatment) was 91.4% in the treatment group and 39.4% in the placebo group. The final clinical response rate at the 12-month followup examination was 85.7% (31 of 35) in the treatment group and 39.4% (13 of 33) in the placebo group (P less than or equal to 0.001). In general, the treatment was well tolerated and was never interrupted because of adverse effects. The number of adverse effects reported in the placebo group was lower than in the treatment group (16 events versus 30 events). All adverse effects reported by patients disappeared within I week of completing the treatment. Our findings show that the combination of paromomycin with methylbenzethonium chloride for 20 days is a good alternative for antimonial treatments of cutaneous leishmaniasis in Guatemala.
| Item Type: | Article |
|---|---|
| Subjects: | QV Pharmacology > QV 38 Drug action. QX Parasitology > Protozoa > QX 70 Mastigophora. (e.g., Giardia. Trichomonas. Trypanosoma. Leishmania) WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WR Dermatology > Parasitic Skin Diseases > WR 350 Tropical diseases of the skin. Mucocutaneous leishmaniasis. Leishmaniasis |
| Digital Object Identifer (DOI): | https://doi.org/10.4269/ajtmh.2001.65.466 |
| Depositing User: | Martin Chapman |
| Date Deposited: | 07 Apr 2014 11:56 |
| Last Modified: | 22 Nov 2024 13:44 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/3102 |
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