A systematic review of randomized controlled trials of prenatal and postnatal vitamin A supplementation of HIV-infected women

Kongnyuy, Eugene J., Wiysonge, C. S. and Shey, M. S. (2009) 'A systematic review of randomized controlled trials of prenatal and postnatal vitamin A supplementation of HIV-infected women'. International Journal of Gynecology & Obstetrics, Vol 104, Issue 1, pp. 5-8.

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Abstract

We searched the Cochrane Library, MEDLINE, EMBASE, AIDSearch, and Gateway to assess the effect of prenatal and/or postnatal vitamin A supplementation on the risk of mother-to-child transmission (MTCT) of HIV and other pregnancy outcomes. We included 5 trials totaling 7528 women (4 trials of prenatal and I trial of postnatal supplementation). Overall, there was no evidence of an effect of prenatal and/or postnatal vitamin A supplementation on the risk of MTCT of HIV (Relative Risk [RR] 1.06, 95% Confidence Interval [CI] 0.89-1.26). However, prenatal vitamin A supplementation significantly improved birth weight (weighted mean difference 89.78; 95% CI, 84.73-94.83), but there was no evidence of an effect on stillbirths (RR 0.99; 95% CI, 0.68-1.43), preterm births (RR 0.88: 95% CI. 0.65-1.19), death before 24 months among live births (RR 1.08; 95% CI, 0.91-1.29), and maternal death (RR 0.83; 95% CI, 0.59-1.17). The available evidence does not support vitamin A supplementation of HIV-infected pregnant and lactating women, despite improvement in birth weight. (C) 2008 International Federation of Gynecology and Obstetrics, Published by Elsevier Ireland Ltd. All tights reserved.

Item Type:	Article
Additional Information:	396VQ Times Cited:0 Cited References Count:29
Uncontrolled Keywords:	vitamin a supplementation hiv infection mother-to-child transmission prenatal period postnatal period to-child transmission vertical transmission night blindness united-states deficiency pregnancy mortality metaanalysis nepal born birth weight
Subjects:	WA Public Health > WA 30 Socioeconomic factors in public health (General) WA Public Health > Preventive Medicine > WA 108 Preventive health services. Preventive medicine. Travel Medicine. WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.4 Epidemiology WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.6 Prevention and control WQ Obstetrics > Childbirth. Prenatal Care > WQ 175 Prenatal care WQ Obstetrics > Pregnancy Complications > WQ 240 Pregnancy complications (General) WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WQ Obstetrics > WQ 100 General works WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications WQ Obstetrics > Pregnancy > WQ 200 General works WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 772 Non-prescription drugs
Faculty: Department:	Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.ijgo.2008.08.023
Depositing User:	Users 19 not found.
Date Deposited:	28 May 2010 11:20
Last Modified:	17 Jul 2020 10:58
URI:	https://archive.lstmed.ac.uk/id/eprint/313

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