Use of fecal occult blood tests as epidemiologic indicators of morbidity associated with intestinal schistosomiasis during preventive chemotherapy in young children.

Betson, Martha, Sousa-Figueiredo, J.C., Kabatereine, Narcis B and Stothard, Russell ORCID: https://orcid.org/0000-0002-9370-3420 (2012) 'Use of fecal occult blood tests as epidemiologic indicators of morbidity associated with intestinal schistosomiasis during preventive chemotherapy in young children.'. American Journal of Tropical Medicine and Hygiene, Vol 87, Issue 4, pp. 694-700.

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Abstract

There is a need for field-applicable markers to assess morbidity associated with intestinal schistosomiasis, especially in the context of preventive chemotherapy in young children. We investigated whether fecal occult blood (FOB) point-of-care tests could be used to assess intestinal pathology over a 12-month period in a cohort of 382 children (< 5 years of age). We found a strong association between egg-patent schistosomiasis and FOB at baseline (odds ratio [OR] = 3.1, P < 0.0001), 6 months (OR = 3.4, P < 0.0001), and 12 months (OR = 3.5, P < 0.0001), despite repeated chemotherapy. There were tendencies for prevalence of FOB to decrease in children who became egg negative and increase in those who became egg positive. Our results demonstrate overt disease in children less than five years of age. We therefore propose that FOB is useful for assessing dynamics of intestinal morbidity in young children at the community level and monitoring changes in morbidity after mass chemotherapy.

Item Type:	Article
Subjects:	QX Parasitology > Helminths. Annelida > QX 355 Schistosoma QY Clinical Pathology > Diagnostic Tests > QY 160 Feces WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis WS Pediatrics > By Age Groups > WS 440 Preschool child
Digital Object Identifer (DOI):	https://doi.org/10.4269/ajtmh.2012.12-0059
Depositing User:	Mary Creegan
Date Deposited:	12 Apr 2013 12:19
Last Modified:	02 Dec 2019 12:52
URI:	https://archive.lstmed.ac.uk/id/eprint/3277

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