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A proteomic approach to identify proteins from trichuris trichiura extract with immunomodulatory effects.

Santos, Leonardo N, Gallo, Margareth B C, Silva, Eduardo S, Figueiredo, Camila Av, Cooper, Philip, Barreto, Maurício L, Loureiro, Sebastião, Pontes-de-Carvalho, Lain C and Alcantara-Neves, Neuza M (2013) 'A proteomic approach to identify proteins from trichuris trichiura extract with immunomodulatory effects.'. Parasite immunology, Vol 35, Issue 5-6, pp. 188-193.

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Infections with Trichuris trichiura and other trichurid nematodes have been reported to display protective effects against atopy, allergic and autoimmune diseases. The aims of the present study were to investigate the immunomodulatory properties of T. trichiura adult worm extract (TtE) and its fractions (TtEFs) on the production of cytokines by peripheral blood mononuclear cells and to identify their proteinaceous components. Fourteen TtEFs were obtained by ion exchange chromatography and tested for effects on cytokine production by peripheral blood mononuclear cells. The molecular constituents of the six most active fractions were evaluated using nano-LC/mass spectrometry. The homology between T. trichiura and the related nematode Trichinella spiralis was used to identify 12 proteins in TtEFs. Among those identified, fructose biphosphate aldolase, a homologue of macrophage migration inhibitory factor and heat shock protein 70 may contribute to the immunomodulatory effects of TtEFs. The identification of such proteins could lead to the development of novel drugs for the therapy of allergic and other inflammatory diseases. © 2013 Blackwell Publishing Ltd.

Item Type: Article
Subjects: QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.5 DNA.
QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General)
QX Parasitology > Helminths. Annelida > QX 203 Nematoda
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 860 Trichuriasis. Oxyuriasis
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):
Depositing User: Mary Creegan
Date Deposited: 02 May 2013 09:54
Last Modified: 06 Feb 2018 13:06


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