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Walker, Patrick G.T., Griffin, Jamie T., Cairns, Matt, Rogerson, Stephen J., van Eijk, Anna 
ORCID: https://orcid.org/0000-0003-1635-1289, terKuile, Feiko ORCID: https://orcid.org/0000-0003-3663-5617 and Ghani, Azra C.
(2013)
'A model of parity-dependent immunity to placental malaria'. Nature Communications, Vol 4, Article no. 1609.
Abstract
Plasmodium falciparum placental infection during pregnancy is harmful for both mother and child. Protection from placental infection is parity-dependent, that is, acquired over consecutive pregnancies. However, the infection status of the placenta can only be assessed at delivery. Here, to better understand the mechanism underlying this parity-dependence, we fitted a model linking malaria dynamics within the general population to observed placental histology. Our results suggest that immunity resulting in less prolonged infection is a greater determinant of the parity-specific patterns than immunity that prevents placental sequestration. Our results also suggest the time when maternal blood first flows into the placenta is a high-risk period. Therefore, preventative strategies implementable before or early in pregnancy, such as insecticide-treated net usage in women of child-bearing age or any future vaccine, could substantially reduce the number of women who experience placental infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Biological sciences; Immunology; Medical research |
| Subjects: | WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WP Gynecology > Anatomy. Diseases. Injuries > WP 140 Diseases (General) |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/ncomms2605 |
| Depositing User: | Users 27 not found. |
| Date Deposited: | 17 Mar 2014 16:46 |
| Last Modified: | 25 Jan 2022 10:06 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/3399 |
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