Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.

Esser, Claudia, Bachmann, Anna, Kuhn, Daniela, Schuldt, Kathrin, Förster, Birgit, Thiel, Meike, May, Jürgen, Koch-Nolte, Friedrich, Yáñez-Mó, María, Sánchez-Madrid, Francisco, Schinkel, Alfred H, Jalkanen, Sirpa, Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164, Bruchhaus, Iris and Horstmann, Rolf D (2014) 'Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.'. Cellular Microbiology, Vol 16, Issue 5, pp. 701-708.

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Abstract

The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties.

Item Type:	Article
Subjects:	QS Anatomy > Histology > QS 532.5.E7 Epithelium QU Biochemistry > Cells and Genetics > QU 375 Cell physiology QX Parasitology > Protozoa > QX 135 Plasmodia WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 150 Erythrocytes
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1111/cmi.12270
Depositing User:	Mary Creegan
Date Deposited:	23 Apr 2014 11:59
Last Modified:	17 Jul 2019 14:14
URI:	https://archive.lstmed.ac.uk/id/eprint/3665

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