Moxon, Christopher A., Chisala, Ngawina V, Wassmer, Samuel C, Taylor, Terrie E, Seydel, Karl B, Molyneux, Malcolm E, Faragher, Brian, Kennedy, Neil, Toh, Cheng-Hock, Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 and Heyderman, Robert (2014) 'Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children.'. Journal of Infectious Disease, Vol 209, Issue 4, pp. 610-615.
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Abstract
Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.
Item Type: | Article |
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Subjects: | QS Anatomy > Histology > QS 532.5.E7 Epithelium QU Biochemistry > Cells and Genetics > QU 375 Cell physiology QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WS Pediatrics > WS 20 Research (General) |
Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology Clinical Sciences & International Health > Clinical Sciences Department |
Digital Object Identifer (DOI): | https://doi.org/10.1093/infdis/jit419 |
Depositing User: | Mary Creegan |
Date Deposited: | 16 Apr 2014 09:29 |
Last Modified: | 17 Aug 2022 08:57 |
URI: | https://archive.lstmed.ac.uk/id/eprint/3666 |
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