The GenoType® MTBDRsltest for resistance to second-line anti-tuberculosis drugs (Protocol)

Theron, Grant, Peter, Jonny, Barnard, Marinus, Donegan, Sarah, Warren, Rob, Steingart, Karen, Dheda, Keertan and Theron, Grant (2013) 'The GenoType® MTBDRsltest for resistance to second-line anti-tuberculosis drugs (Protocol)'. Cochrane Database of Systematic Reviews, Issue 8, CD010705.

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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of resistance to the fluoroquinolones in patient specimens or culture isolates confirmed as TB positive.

To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of resistance to second-line injectable drugs in patient specimens or culture isolates confirmed as TB positive.

To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of XDR-TB in patient specimens or culture isolates confirmed as TB positive.

Purpose of index test: GenoType® MTBDRsl used as an initial test replacing phenotypic culture-based DST as the initial test.

We plan to investigate heterogeneity in relation to the reference tests (genetic sequencing, culture-based DST, and culture-based DST followed by genetic sequencing), as well as by type of testing (indirect or direct). We also plan to investigate heterogeneity in relation to HIV status, conditions of the specimens (fresh or frozen, volume of specimen) and patient population (patients suspected of having MDR-TB or XDR-TB).

Item Type:	Article
Additional Information:	This protocol is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2013, Issue 8, CD010705. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.
Subjects:	QV Pharmacology > QV 38 Drug action. QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified. QY Clinical Pathology > QY 25 Laboratory techniques and procedure WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis WF Respiratory System > Tuberculosis > WF 360 Drug therapy
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1002/14651858.CD010705
Depositing User:	Martin Chapman
Date Deposited:	03 Nov 2014 16:02
Last Modified:	06 Feb 2018 13:07
URI:	https://archive.lstmed.ac.uk/id/eprint/4520

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