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Parkes-Ratanshi, Rosalind, Katende, David, Levin, Jonathan, Wakeham, Katie, Heiner, Grosskurth, Kamali, Anatoli and Lalloo, David 
ORCID: https://orcid.org/0000-0001-7680-2200
(2014)
'Development of Severe Anemia and
Changes in Hemoglobin in a Cohort of
HIV-Infected Ugandan Adults Receiving
Zidovudine-, Stavudine-, and
Tenofovir-Containing Antiretroviral Regimens'. Journal of the International Association of Providers of AIDS Care, Vol 14, Issue 5, pp. 455-462.
Abstract
Introduction
Anemia is a common problem in HIV in sub-Saharan Africa. We describe the contribution of antiretroviral therapy (ART) regimen to the incidence of anemia and changes in hemoglobin (Hb) in HIV-infected patients in Uganda.
Methods
This study was nested in a prevention of cryptococcal disease trial (CRYPTOPRO; ISCRTN7648152). Patients received 3 different backbones of nucleoside reverse transcriptase inhibitor in a nonrandomized manner.
Results
Of the 852 patients (161 on zidovudine [ZDV], 628 on stavudine [d4T], and 63 on tenofovir [TDF]; all received lamuvidine), the risk of developing grade 4 anemia was higher (adjusted hazard ratio 2.7) for those receiving ZDV than those receiving d4T. Those receivingd4T had a higher average increase in Hb than those receiving ZDV (P = .024) or TDF (P = .014).
Conclusion
In this observational study, ZDV was associated with severe anemia compared to d4T or TDF; those receiving ZDV and TDF had smaller increases in Hb after ART initiation. We encourage publication of data on cohorts using TDF from Africa.
| Item Type: | Article |
|---|---|
| Subjects: | WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.2 Therapy WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 155 Anemia |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1177/2325957414557264 |
| Depositing User: | Annmarie Hand |
| Date Deposited: | 15 Dec 2014 10:59 |
| Last Modified: | 22 Feb 2018 15:58 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/4617 |
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