A Retrospective Survey of HIV Drug Resistance Among Patients 1 Year After Initiation of Antiretroviral Therapy at 4 Clinics in Malawi

Wadonda-Kabondo, N., Hedt, B. L., van Oosterhout, J. J., Moyo, K., Limbambala, E., Bello, G., Chilima, B., Schouten, E., Harries, A., Massaquoi, M., Porter, C., Weigel, Ralf ORCID: https://orcid.org/0000-0001-9034-2634, Hosseinipour, M., Aberle-Grasse, J., Jordan, M. R., Kabuluzi, S. and Bennett, D. E. (2012) 'A Retrospective Survey of HIV Drug Resistance Among Patients 1 Year After Initiation of Antiretroviral Therapy at 4 Clinics in Malawi'. Clinical Infectious Diseases, Vol 54, Issue Supp 4, S355-S361.

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Abstract

In 2004, Malawi began scaling up its national antiretroviral therapy (ART) program. Because of limited treatment options, population-level surveillance of acquired human immunodeficiency virus drug resistance (HIVDR) is critical to ensuring long-term treatment success. The World Health Organization target for clinic-level HIVDR prevention at 12 months after ART initiation is ≥70%. In 2007, viral load and HIVDR genotyping was performed in a retrospective cohort of 596 patients at 4 ART clinics. Overall, HIVDR prevention (using viral load ≤400 copies/mL) was 72% (95% confidence interval [CI], 67%–77%; range by site, 60%–83%) and detected HIVDR was 3.4% (95% CI, 1.8%–5.8%; range by site, 2.5%–4.7%). Results demonstrate virological suppression and HIVDR consistent with previous reports from sub-Saharan Africa. High rates of attrition because of loss to follow-up were noted and merit attention.

Item Type:	Article
Subjects:	W General Medicine. Health Professions > Health Services. Patients and Patient Advocacy > W 85 Patients. Attitude and compliance WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.2 Therapy WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.6 Prevention and control
Digital Object Identifer (DOI):	https://doi.org/10.1093/cid/cis004
Depositing User:	Martin Chapman
Date Deposited:	10 Dec 2014 15:52
Last Modified:	15 Jun 2018 14:36
URI:	https://archive.lstmed.ac.uk/id/eprint/4638

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