Tools
Tools
Ntinginya, E. N., Squire, Bertie 
ORCID: https://orcid.org/0000-0001-7173-9038, Millington, Kerry, Mtafya, B., Saathoff, E., Heinrich, N., Rojas-Ponce, G., Kowuor, D., Maboko, L., Reither, K., Clowes, P., Hoelscher, M. and Rachow, A.
(2012)
'Performance of the Xpert® MTB/RIF assay in an active case-finding strategy: a pilot study from Tanzania [Short communication]'. International Journal of Tuberculosis and Lung Disease, Vol 16, Issue 11, pp. 1468-1470.
Abstract
In this pilot study, we evaluated the Xpert® MTB/RIF assay in an active case-finding strategy, using two spot sputum samples collected within a 1-hour interval from household contacts of smear-positive TB index cases. Tuberculosis (TB) confirmed by culture served as the reference standard. Among 219 enrolled contacts, the yield of active TB was 2.3%. While the sensitivity of smear microscopy was 60% (95%CI 14.7–94.7), Xpert MTB/RIF achieved a sensitivity of 100% (95%CI 47.81–100.0). All culture-confirmed cases tested positive by Xpert MTB/RIF on the first submitted sample, suggesting that the evaluation of only one sample could be sufficient for TB diagnosis in this context.
| Item Type: | Article |
|---|---|
| Subjects: | QY Clinical Pathology > Diagnostic Tests > QY 120 Sputum QY Clinical Pathology > QY 25 Laboratory techniques and procedure WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WF Respiratory System > Tuberculosis > WF 205 Epidemiology WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis |
| Faculty: Department: | Groups (2002 - 2012) > Clinical Group |
| Digital Object Identifer (DOI): | https://doi.org/10.5588/ijtld.12.0127 |
| Depositing User: | Martin Chapman |
| Date Deposited: | 07 Jan 2015 10:55 |
| Last Modified: | 13 Nov 2019 11:22 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/4718 |
Statistics
Actions (login required)
 |
Edit Item |