Parental smoking and childhood obesity: higher effect estimates for maternal smoking in pregnancy compared with paternal smoking--a meta-analysis

Riedel, C., Schonberger, K., Yang, S., Koshy, Gibby, Chen, Y.-C., Gopinath, B., Ziebarth, S. and von Kries, R. (2014) 'Parental smoking and childhood obesity: higher effect estimates for maternal smoking in pregnancy compared with paternal smoking--a meta-analysis'. International Journal of Epidemiology, Vol 43, Issue 5, pp. 1593-1606.

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Abstract

Background: Some studies reported similar effect estimates for the impact of maternal smoking in pregnancy and paternal smoking on childhood obesity, whereas others suggested higher effects for maternal smoking. We performed a meta-analysis to compare the effect of in utero exposure to maternal smoking and that of paternal or household smoking exposure in utero or after birth with mutual adjustment.

Methods: Meta-analysis of observational studies identified in MEDLINE, EMBASE and Web of Knowledge published in 1900–2013. Study inclusion criterion was assessment of the association of maternal smoking during pregnancy and paternal or household smoking (anyone living in the household who smokes) at any time with childhood overweight and obesity. The analyses were based on all studies with mutually adjusted effect estimates for maternal and paternal/household smoking applying a random-effects model.

Results: Data for 109 838 mother/child pairs were reported in 12 studies. The pooled odds ratios (ORs) for overweight 1.33 [95% confidence interval (CI) 1.23;1.44] (n = 6, I2 = 0.00%) and obesity 1.60 (95% CI 1.37;1.88) (n = 4, I2 = 32.47%) for maternal smoking during pregnancy were higher than for paternal smoking: 1.07 (95% CI 1.00;1.16) (n = 6, I2 = 41.34%) and 1.23 (95% CI 1.10;1.38) (n = 4, I2 = 14.61%), respectively. Similar estimates with widely overlapping confidence limits were found for maternal smoking during pregnancy and childhood overweight and obesity: 1.35 (95% CI 1.20;1.51) (n = 3, I2 = 0.00%) and 1.28 (95% CI 1.07;1.54) (n = 3, I2 = 0.00%) compared with household smoking 1.22 (95% CI 1.06;1.39) (n = 3, I2 = 72.14%) and 1.31 (95% CI 1.15;1.50)] (n = 3, I2 = 0.00%).

Conclusions: Higher effect estimates for maternal smoking in pregnancy compared with paternal smoking in mutually adjusted models may suggest a direct intrauterine effect.

Item Type:	Article
Subjects:	WA Public Health > WA 105 Epidemiology WA Public Health > Air pollution > WA 754 Pollution and pollutants (incl. tobacco pollution; passive smoking) WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 115 Nutritional requirements. Nutrition disorders WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 130 In childhood
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1093/ije/dyu150
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	12 Jan 2015 11:57
Last Modified:	06 Feb 2018 13:08
URI:	https://archive.lstmed.ac.uk/id/eprint/4738

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