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Sickle-cell disease in Malawian children is associated with restrictive spirometry: a cross-sectional survey

Cook, J., Jefferis, O., Matchere, P., Mbale, E. and Rylance, Jamie ORCID: (2013) 'Sickle-cell disease in Malawian children is associated with restrictive spirometry: a cross-sectional survey'. International Journal of Tuberculosis and Lung Disease, Vol 17, Issue 9, pp. 1235-1238.

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BACKGROUND: A proportion of children with sickle-cell disease (SCD) demonstrate clinical findings consistent with the diagnosis of asthma. These children are at increased risk of complications, including acute chest syndrome.

OBJECTIVE: To assess lung function and symptoms of asthma in children with SCD in Blantyre, Malawi.

DESIGN: Twenty-five children aged 7–16 years with electrophoretically confirmed SCD were recruited to undergo spirometry and questionnaire screening of asthma symptoms. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio were compared with local and international reference ranges. Symptoms were assessed using the International Study of Asthma and Allergies in Childhood questionnaire.

RESULTS: Mean spirometric indices, represented as Z-scores derived from international reference ranges, were low: FEV1 −1.64 (95%CI −2.04 to −1.23), FVC −1.49 (95%CI −1.90 to −1.09), FEV1/FVC −0.39 (95%CI −0.76 to −0.03). Comparison with local reference ranges, represented as percentage of predicted value, revealed similar impairments: FEV1 86.9 (95%CI 81.1 to 92.7), FVC 89.0 (95%CI 83.5 to 94.4), FEV1/FVC ratio 97.7 (95%CI 95.4 to 99.9). The prevalence of wheeze was 16.7%.

CONCLUSION: We present spirometric abnormalities suggestive of restrictive lung disease with no evidence of obstructive defects or increased prevalence of wheeze.

Item Type: Article
Subjects: WF Respiratory System > WF 140 Diseases of the respiratory system (General)
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 170 Hemolytic anemia (e.g., Sickle cell anemia)
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 280 Respiratory system
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Lynn Roberts-Maloney
Date Deposited: 17 Feb 2015 12:27
Last Modified: 13 Mar 2020 16:19


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