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Olliaro, Piero L., Vaillant, Michel, Hayes, Daniel, Montresor, Antonio and Chitsulo, Lester (2013) 'Practical dosing of praziquantel for schistosomiasis in preschool-aged children'. Tropical Medicine & International Health, Vol 18, Issue 9, pp. 1085-1089.
Full text not available from this repository.Abstract
Objective
Schistosomiasis is known to occur in preschool-aged children, but achieving accurate dosing of praziquantel in its current form is challenging. While waiting for a paediatric formulation, there is a need to develop a means for using the available products to treat this age group. Current 600-mg tablets are differently scored to give units of 150 mg (a quarter of a tablet) or 300 mg (half a tablet).
Methods
We examined several dosing schemes to dose accurately (40-60 mg/kg) children aged 3–72 months (weight range 4–25 kg, based on available weight-for-age growth references from sub-Saharan Africa and Brazil, n = 106,230).
Results
Adequate dosing can be achieved with formulations that can be split into four 150 mg quarters for children weighing 5 kg or more, and with tablets than can be split into two 300 mg halves for children weighing 10 kg or more. Giving ½ tablet for 5–7 kg; ¾ tablet for 8–10 kg; 1 tablet for 11–15 kg; 1 ½ tablet for 16–21 kg; and two tablets for 22–25 kg will have 100% of subjects correctly dosed within the target 40–60 mg/kg range.
Conclusions
Formulations that can be divided into four parts (to give 150 mg increments) are preferred for children weighing less than 11 kg; the same dosing can be applied with 600 mf praziquantel formulations that can be divided into four quarters or two halves from 11 kg body weight.
| Item Type: | Article |
|---|---|
| Subjects: | QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 253 Anthelmintics QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 748 Prescription writing. Dosage. Dosage calculations WA Public Health > Preventive Medicine > WA 108 Preventive health services. Preventive medicine. Travel Medicine. WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis WS Pediatrics > By Age Groups > WS 440 Preschool child |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1111/tmi.12152 |
| Depositing User: | Lynn Roberts-Maloney |
| Date Deposited: | 05 Mar 2015 13:16 |
| Last Modified: | 06 Feb 2018 13:09 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/4987 |
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