Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

Ogwang, C., Kimani, D., Edwards, N. J., Roberts, R., Mwacharo, J., Bowyer, G., Bliss, C., Hodgson, S. H., Njuguna, P., Viebig, N. K., Nicosia, A., Gitau, E., Douglas, S., Illingworth, J., Marsh, K., Lawrie, A., Imoukhuede, E. B., Ewer, K., Urban, Britta ORCID: https://orcid.org/0000-0002-4197-8393, S. Hill, A. V. and Bejon, P. (2015) 'Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults'. Science Translational Medicine, Vol 7, Issue 286, 286re5.

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Abstract

Protective immunity to the liver stage of the malaria parasite can be conferred by vaccine-induced T cells, but no subunit vaccination approach based on cellular immunity has shown efficacy in field studies. We randomly allocated 121 healthy adult male volunteers in Kilifi, Kenya, to vaccination with the recombinant viral vectors chimpanzee adenovirus 63 (ChAd63) and modified vaccinia Ankara (MVA), both encoding the malaria peptide sequence ME-TRAP (the multiple epitope string and thrombospondin-related adhesion protein), or to vaccination with rabies vaccine as a control. We gave antimalarials to clear parasitemia and conducted PCR (polymerase chain reaction) analysis on blood samples three times a week to identify infection with the malaria parasite Plasmodium falciparum. On Cox regression, vaccination reduced the risk of infection by 67% [95% confidence interval (CI), 33 to 83%; P = 0.002] during 8 weeks of monitoring. T cell responses to TRAP peptides 21 to 30 were significantly associated with protection (hazard ratio, 0.24; 95% CI, 0.08 to 0.75; P = 0.016).

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids QX Parasitology > Protozoa > QX 135 Plasmodia WA Public Health > Preventive Medicine > WA 115 Immunization WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1126/scitranslmed.aaa2373
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	20 Jul 2015 13:29
Last Modified:	18 Oct 2017 13:35
URI:	https://archive.lstmed.ac.uk/id/eprint/5245

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