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Pedrini, Maura, Moraleda, Cinta, Macete, Eusebio, Gondo, Kizito, Brabin, Bernard and Menendez, Clara (2015) 'Clinical, nutritional and immunological characteristics of HIV-infected children in an area of high HIV prevalence'. Journal of Tropical Pediatrics, Vol 61, Issue 4, pp. 286-294.
Full text not available from this repository.Abstract
Objectives
To evaluate the clinical, nutritional and neurodevelopment status of HIV-infected children in a high HIV prevalence area.
Methods
All HIV-infected children under 15 years of age attending an outpatient clinic of Mozambique between April and May 2010 were recruited. Clinical data were collected and physical examination was performed.
Results
In all, 140 children were recruited. The median age at HIV diagnosis was 2.1 years. Fifty-one percent of the children were classified in WHO clinical Stages 3 or 4. Median age of antiretroviral treatment commencement was 3.9 years. Overall, 68% were undernourished, mainly stunted. Forty-four percent failed to pass the national psychomotor developmental test.
Conclusions
The pathways for early HIV diagnosis and start of antiretrovirals in children should be improved in Mozambique. Malnutrition, especially stunting, and developmental delay were highly prevalent. Further research focused on early diagnosis of neurocognitive disorders and on the indications of antiretroviral treatment commencement based on chronic malnutrition is required.
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