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Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil

Fawkner-Corbett, DW, Khoo, SK, Duarte, MC, Bezerra, PGM, Bochkov, YA, Gern, JE, Le Souef, PN, McNamara, PS, Rose, K, Fonceca, AM, Hopkins, M, Britto, M, Cuevas, Luis ORCID: and Correia, JB (2015) 'Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil'. Journal of Medical Virology, Vol 88, Issue 1, pp. 58-63.

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Human rhinovirus (RV) is a common cause of acute respiratory infection (ARI) in children. We aimed to characterise the clinical and demographic features associated with different RV species detected in children attending hospital with ARI, from low-income families in North-east Brazil.


Nasopharyngeal aspirates were collected from 630 children <5years with ARI. Clinical diagnosis and disease severity were also recorded. Samples were analysed by multiplex PCR for 18 viral and atypical bacterial pathogens; RV positive samples underwent partial sequencing to determine species and type.


RV was the fourth commonest pathogen accounting for 18.7% of pathogens detected. RV was commonly detected in children with bronchiolitis, pneumonia and asthma/episodic viral wheeze (EVW). Species and type were assigned in 112 cases (73% RV-A; 27% RV-C; 0% RV-B). Generally, there were no differences in clinical or demographic characteristics between those infected with RV-A and RV-C. However, in children with asthma/EVW, RV-C was detected relatively more frequently than RV-A (23% vs 5%; p = 0.04).


Our findings highlight RV as a potentially important pathogen in this setting. Generally, clinical and demographic features were similar in children in whom RV A and C species were detected. However, RV-C was more frequently found in children with asthma/EVW than RV-A. This article is protected by copyright. All rights reserved

Item Type: Article
Subjects: QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology
WF Respiratory System > WF 140 Diseases of the respiratory system (General)
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 280 Respiratory system
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Lynn Roberts-Maloney
Date Deposited: 29 Sep 2015 09:12
Last Modified: 06 Feb 2018 13:10


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