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An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis survey


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Cano, Jorge, Moraga, Paula, Nikolay, Birgit, Rebollo, Maria P., Okorie, Patricia N., Davies, Emmanuel, Njenga, Sammy M., Bockarie, Moses and Brooker, Simon J. (2015) 'An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis survey'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 109, Issue 8, pp. 529-531.

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The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.

This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.

Results and Conclusions
In some settings there was a very large disparity, up to 40–70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.

Item Type: Article
Subjects: QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 573 Antigens
QX Parasitology > QX 20 Research (General)
QX Parasitology > Helminths. Annelida > QX 301 Filarioidea
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General)
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):
Depositing User: Lynn Roberts-Maloney
Date Deposited: 24 Sep 2015 12:30
Last Modified: 06 Feb 2018 13:10


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