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Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children: An Update

Graham, Stephen M., Cuevas, Luis ORCID:, Jean-Philippe, Patrick, Browning, Renee, Casenghi, Martina, Detjen, Anne K., Gnanashanmugam, Devasena, Hesseling, Anneke C., Kampmann, Beate, Mandalakas, Anna, Marais, Ben J., Schito, Marco, Spiegel, Hans M. L., Starke, Jeffrey R., Worrell, Carol and Zar, Heather J. (2015) 'Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children: An Update'. Clinical Infectious Diseases, Vol 61, Issue S3, S179-S187.

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Consensus case definitions for childhood tuberculosis have been proposed by an international expert panel, aiming to standardize the reporting of cases in research focusing on the diagnosis of intrathoracic tuberculosis in children. These definitions are intended for tuberculosis diagnostic evaluation studies of symptomatic children with clinical suspicion of intrathoracic tuberculosis, and were not intended to predefine inclusion criteria into such studies. Feedback from researchers suggested that further clarification was required and that these case definitions could be further improved. Particular concerns were the perceived complexity and overlap of some case definitions, as well as the potential exclusion of children with acute onset of symptoms or less severe disease. The updated case definitions proposed here incorporate a number of key changes that aim to reduce complexity and improve research performance, while maintaining the original focus on symptomatic children suspected of having intrathoracic tuberculosis. The changes proposed should enhance harmonized classification for intrathoracic tuberculosis disease in children across studies, resulting in greater comparability and the much-needed ability to pool study results.

Item Type: Article
Additional Information: This article appears in: Advances in Tuberculosis Research: A Blueprint for Opportunities
Subjects: WF Respiratory System > Tuberculosis > WF 205 Epidemiology
WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
WF Respiratory System > Tuberculosis > WF 415 Tuberculosis in childhood
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 280 Respiratory system
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Lynn Roberts-Maloney
Date Deposited: 29 Oct 2015 11:45
Last Modified: 15 Jun 2018 14:42


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