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Varo, Rosauro, Buck, W Chris, Kazembe, Peter N, Phiri, Sam, Andrianarimanana, Diavolana and Weigel, Ralf 
ORCID: https://orcid.org/0000-0001-9034-2634
(2016)
'Seroprevalence of CMV, HSV-2 and HBV among HIV-Infected Malawian Children: A Cross-sectional Survey'. Journal of Tropical Pediatrics, Vol 62, Issue 3, pp. 220-226.
Abstract
Background:
Little is known about viral co-infections in African human immunodeficiency virus (HIV)-infected children. We examined the prevalence of seromarkers for cytomegalovirus (CMV), herpes simplex virus type 2 (HSV-2) and hepatitis B virus (HBV) infections among HIV-infected, antiretroviral treatment (ART)-naïve children in Lilongwe, Malawi.
Methods:
Ninety-one serum samples were tested for IgG and IgM antibodies to CMV, and IgG antibodies to HSV-2 and hepatitis B surface antigen (HBsAg). Baseline demographic, clinical and laboratory data were abstracted from electronic records.
Results:
CMV IgG was the most common positive result in all age groups (in 73% of children <1 year, and 100% in all other groups). Three patients were CMV IgM positive (3.3%), suggesting acute infection. HSV-2 IgG was positive in four patients (4.4%), and HBsAg in two (2.2%).
Conclusions:
CMV infection occurred early in life, and few children had specific signs of CMV infection at the time of ART initiation. Unrecognized HBV infection represents opportunities for testing and treatment of HIV/HBV co-infected children.
| Item Type: | Article |
|---|---|
| Subjects: | QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications WS Pediatrics > Diseases of Children and Adolescents > General Diseases > WS 200 General works |
| Faculty: Department: | Clinical Sciences & International Health > International Public Health Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1093/tropej/fmv105 |
| Depositing User: | Jessica Jones |
| Date Deposited: | 14 Mar 2016 15:33 |
| Last Modified: | 06 Feb 2018 13:12 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/5760 |
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