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Inflammation and Change in Body Weight with Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-infected Adults.

Mave, Vidya, Erlandson, Kristine M, Gupte, Nikhil, Balgopal, Ashwin, Asmuth, David M, Campbell, Thomas B, Smeaton, Laura, Kumarasamy, Nagalingeswaran, Hakim, James, Santos, Breno, Riviere, Cynthia, Hosseinipour, Mina C, Sugandhavesa, Patcharaphan, Infante, Rosa, Pillay, Sandy, Cardoso, Sandra W, Tripathy, Srikanth, Mwelase, Noluthando, Berendes, Sima, Andrade, Bruno B, Thomas, David L, Bollinger, Robert C and Gupta, Amita (2016) 'Inflammation and Change in Body Weight with Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-infected Adults.'. Journal of Infectious Disease, Vol 214, Issue 1, pp. 65-72.

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Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation in HIV is unknown.

Among a random virologically suppressed participants of the PEARLS trial, inflammatory markers were measured at weeks 0, 24, and 48 post-antiretroviral therapy (ART). Associations between baseline and change in body mass index (BMI) and inflammation changes were assessed using random effects models.

Of 246 participants, 27% were overweight/obese (BMI≥25 kg/m(2)) and 8% were underweight (BMI<18.5 kg/m(2)) at baseline. After 48 weeks, 37% were overweight/obese and 3% were underweight. While many inflammatory markers decreased 48 weeks after ART in the overall group, the decrease in CRP was smaller in overweight/obese participants (p=0.01) and the decreases in both CRP (p=0.01) and IL-18 (p=0.02) were smaller in underweight participants. Each 1 unit gain in BMI among overweight/obese participants was associated with a 0.02 log10 increase in sCD14 (p=0.05), while each 1 unit BMI gain among underweight participants was associated with 9.32 mg/L decrease in CRP (p=0.001).

Being either overweight or underweight at ART initiation was associated with heightened systemic inflammation. While weight gain among overweight/obese persons predicted increased inflammation, weight gain among underweight persons predicted reduced inflammation.

Item Type: Article
Subjects: WB Practice of Medicine > Diagnosis > General Diagnosis > WB 143 Signs and symptoms
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
Faculty: Department: Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):
Depositing User: Helen Fletcher
Date Deposited: 16 Mar 2016 15:07
Last Modified: 07 Dec 2018 10:17


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