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A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever

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Bousfield, Rachel, Thyl, Miliya, Samol, Orng, Rithea, Loet, Sona, Soeng, Chhat, Hor Put, Poda, Sar, Moore, Cartin E., Chheng, Kheng, Kumar, Varun, Day, Nicholas P. J. and Parry, Christopher (2016) 'A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever'. Paediatrics and International Child Health, Vol 36, Issue 2, pp. 118-121.

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Official URL: http://www.tandfonline.com/doi/abs/10.1179/2046905...

Abstract

Background:
Blood cultures are used to confirm a diagnosis of enteric fever but reported sensitivities can be as low as 40%.
Aims:
To determine the factors associated with a negative blood culture in Cambodian children with suspected enteric fever.
Methods:
In a retrospective study of hospitalised Cambodian children given a discharge diagnosis of enteric fever, the following factors associated with a negative blood culture were analysed: age, blood culture volume, prior antibiotic therapy, duration of illness and disease severity.
Results:
In 227 hospitalised Cambodian children with a discharge diagnosis of enteric fever, it was confirmed in 70% by a positive blood culture. There was no association between a negative blood culture and younger age, lower blood volumes for culture, prior antibiotic therapy, a late presentation or milder disease.
Conclusions:
Although blood culture sensitivity was higher than expected, alternative simple, rapid and sensitive tests are needed for diagnosing enteric fever.

Item Type:	Article
Subjects:	QY Clinical Pathology > Blood. Blood Chemistry > QY 400 General works WA Public Health > Health Problems of Special Population Groups > WA 320 Child Welfare. Child Health Services. WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 270 Typhoid fever WS Pediatrics > Diseases of Children and Adolescents > By System > WS 310 Digestive system
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1179/2046905515Y.0000000009
Depositing User:	Jessica Jones
Date Deposited:	03 May 2016 10:03
Last Modified:	06 Feb 2018 13:12
URI:	https://archive.lstmed.ac.uk/id/eprint/5867

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