Antimicrobial susceptibility of uropathogens isolated from Cambodian children

Moore, Catrin E., Sona, Soeng, Poda, Sar, Putchhat, Hor, Kumar, Varun, Sopheary, Sun, Stoesser, Nicole, Bousfield, Rachel, Day, Nicholas and Parry, Christopher (2016) 'Antimicrobial susceptibility of uropathogens isolated from Cambodian children'. Paediatrics and International Child Health, Vol 36, Issue 2, pp. 113-117.

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Abstract

Background:
Bacterial resistance to commonly used antimicrobials is an increasing problem in Asia but information concerning the antimicrobial susceptibility of bacteria causing urinary tract infections (UTIs) in children is limited.
Methods:
This was a 5-year retrospective study of children with suspected UTI attending a paediatric hospital in north-west Cambodia. Urines with a positive culture containing a single organism with a count of >105 colony-forming units (CFU)/ml were considered diagnostic of infection. The organism was identified and the resistance pattern (using CLSI guidelines) and presence of an extended-spectrum β-lactamase (ESBL) phenotype was determined.
Results:
In total, there were 217 episodes of infection, 210 (97%) with Gram-negative bacteria. Escherichia coli was the most common infecting isolate with high levels of resistance to most oral antibiotics, except nitrofurantoin. Nearly half of the E. coli (44%) were extended-spectrum cephalosporin (ESC)-resistant with the proportion increasing significantly over the 5-year period. ESC-resistant E. coli were more likely to be multi-drug-resistant and 91% demonstrated an ESBL phenotype.
Conclusion:
The data highlight the importance of microbiological surveillance of UTIs in children, particularly in areas where there are known to be multiply resistant organisms.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified. WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 290 Escherichia coli infections WS Pediatrics > Diseases of Children and Adolescents > By System > WS 320 Urogenital system WS Pediatrics > By Age Groups > WS 460 Adolescence (General)
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1179/2046905515Y.0000000008
Depositing User:	Jessica Jones
Date Deposited:	12 May 2016 12:37
Last Modified:	09 Aug 2017 01:03
URI:	https://archive.lstmed.ac.uk/id/eprint/5884

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